Effect of silybin on high-fat-induced fatty liver in rats

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چکیده

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Effect of silybin on high-fat-induced fatty liver in rats.

Silybin, a natural antioxidant, has been traditionally used against a variety of liver ailments. To investigate its effect and the underlying mechanisms of action on non-alcoholic fatty liver in rats, we used 60 4-6-week-old male Sprague-Dawley rats to establish fatty liver models by feeding a high-fat diet for 6 weeks. Hepatic enzyme, serum lipid levels, oxidative production, mitochondrial mem...

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Ameliorating effect of Allium Sativum on high-fat diet induced fatty liver in albino rats

OBJECTIVE To assess the hepatoprotective effect provided by fresh garlic on fatty liver induced by high-fat diet. METHODS This experimental study was carried out at BMSI, JPMC from October to November 2008. Thirty adult albino rats, 200-240 gram weight, were divided into three groups. Group A received control diet, Group B received high-fat diet (20 mg butter/100 gm diet) and Group C received...

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Ameliorative Potential of Tamarindus indica on High Fat Diet Induced Nonalcoholic Fatty Liver Disease in Rats

Nonalcoholic fatty liver disease (NAFLD), the prevalence of which is rising globally with current upsurge in obesity, is one of the most frequent causes of chronic liver diseases. The present study evaluated the ameliorative effect of extract of Tamarindus indica seed coat (ETS) on high fat diet (HFD) induced NAFLD, after daily administration at 45, 90, and 180 mg/kg body weight dose levels for...

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Effect of Hydroalcoholic Extract of Tamarix dioica on Liver Histopathological Changes in Rats Fed with High Fat Diet

Background and Objectives: Tamarix dioica is a medicinal herb in Sistan and Baluchestan, which has antidiabetic and antioxidant properties. This research aimed to investigate the effects of the hydro-alcoholic extract of this plant on liver damage caused by a high fat diet.   Methods: In this experimental study, 30 males adult Wistar rats, were randomly divided into 3 equal groups. The first g...

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 2011

ISSN: 0100-879X

DOI: 10.1590/s0100-879x2011007500083